醚桥联双环亚氨基糖衍生物的合成与生物学评价
Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives.
作者信息
Chir Jiun-Ly, Wu Pey-Jiuann, Zou Wei, Bhasin Milan, Juang Wei-Fu, Guo Chao-Qi, Wu An-Tai
机构信息
Biotechnology Center in Southern Taiwan, Academia Sinica, 2F., No. 22, Lane 31, Sec. 1, Huandong Rd., Sinshih Township, Tainan County 744, Taiwan.
出版信息
Carbohydr Res. 2009 Sep 8;344(13):1639-45. doi: 10.1016/j.carres.2009.05.029. Epub 2009 Jun 6.
PMID:19570528
Abstract
Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
摘要
具有醚桥且在C-2和氮原子上带有不同取代基的双环亚氨基糖衍生物已由带有异亚丙基缩醛的C-糖苷合成。研究了这些化合物对几种糖苷酶的活性，结果显示出中等程度的抑制和激活作用。
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