Russell A S, Essery G
Cancer. 1977 Jul;40(1):42-5. doi: 10.1002/1097-0142(197707)40:1<42::aid-cncr2820400109>3.0.co;2-f.
Herpes simplex virus-infected target cells, sensitised with antiviral antibody can be lysed by non-immune human lymphocytes (K-cells). This antibody dependent cell mediated immunity (ADCC) is a very efficient technique for destroying foreign target cells and may play a role in maintaining the localization of recurrent herpetic infections. We have used 51Cr labelled herpes virus infected target cells to examine the K-cell activity of peripheral blood lymphocytes in patients who have either malignant reticuloendothelial diseases or who are receiving cytotoxic and steroid therapy for other reasons. K-cell activity was generally within the normal range in such patients and was surprisingly stable despite the occasional use of relatively large doses of cytotoxic agents. It is unlikely, therefore, that a defect in ADCC is responsible for the dissemination of herpes virus infections that may be seen in association with the above drugs and diseases.
感染单纯疱疹病毒的靶细胞，用抗病毒抗体致敏后可被非免疫性人淋巴细胞（K细胞）裂解。这种抗体依赖性细胞介导的免疫（ADCC）是破坏外来靶细胞的一种非常有效的技术，可能在复发性疱疹感染的局限化过程中发挥作用。我们使用51Cr标记的感染疱疹病毒的靶细胞，来检测患有恶性网状内皮疾病或因其他原因接受细胞毒性和类固醇治疗的患者外周血淋巴细胞的K细胞活性。这类患者的K细胞活性通常在正常范围内，尽管偶尔使用相对大剂量的细胞毒性药物，但其活性仍出人意料地稳定。因此，ADCC缺陷不太可能是与上述药物和疾病相关的疱疹病毒感染播散的原因。
