人类中针对疱疹感染细胞的细胞介导细胞毒性：对抗体的依赖性。
Cell-mediated cytotoxicity to herpes-infected cells in humans: dependence on antibodies.
作者信息
Moller-Larsen A, Heron I, Haahr S
出版信息
Infect Immun. 1977 Apr;16(1):43-7. doi: 10.1128/iai.16.1.43-47.1977.
Abstract
Herpes simplex virus type 1 (HSV-1)-infected human skin fibroblasts were used as target cells in a 51Cr release assay, using peripheral blood mononuclear cells from HSV-seropositive and -seronegative donors as effector cells. Cytotoxicity was exerted by ordinarily prepared lymphoid cells but could be reduced by extensive washing of the effector cells. The antibody dependence of the system was shown by the recovery of activity through addition of positive serum or medium used for the early washes of effector cells. Three donors found to be seronegative in the usual serological tests were shown to be seropositive in this test. It is proposed that the assay can be used as a very sensitive serological test.
摘要
在一项⁵¹Cr释放试验中，单纯疱疹病毒1型（HSV-1）感染的人皮肤成纤维细胞被用作靶细胞，来自HSV血清阳性和血清阴性供体的外周血单个核细胞被用作效应细胞。通常制备的淋巴细胞可产生细胞毒性，但通过对效应细胞进行大量洗涤可降低这种毒性。通过添加阳性血清或用于早期洗涤效应细胞的培养基来恢复活性，表明了该系统对抗体的依赖性。在常规血清学检测中被发现血清阴性的三名供体，在该试验中显示为血清阳性。有人提出，该试验可用作一种非常灵敏的血清学检测方法。
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本文引用的文献
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