Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA.
Clin Pharmacol Ther. 2010 Jan;87(1):122-5. doi: 10.1038/clpt.2009.116. Epub 2009 Jul 1.
Parasitic protozoa cause devastating diseases across large regions of the globe, but a lack of economic incentives has resulted in the limited development of drugs against these "neglected diseases." Transporters expressed in the plasma membranes of these parasites offer potential for the development of new drugs. These permeases could be employed in two distinct strategies for drug development: (i) targeting selective delivery of drugs to the parasite and (ii) developing drugs that inhibit essential parasite permeases.
寄生虫原生动物在全球大片地区引起毁灭性疾病,但缺乏经济激励导致针对这些“被忽视疾病”的药物开发有限。这些寄生虫质膜中表达的转运蛋白为开发新药提供了潜力。这些渗透酶可用于两种不同的药物开发策略:(i) 靶向将药物选择性递送到寄生虫,和 (ii) 开发抑制必需寄生虫渗透酶的药物。