低温条件下预充液中白蛋白浓度对血液黏度的影响。
Influence of albumin concentration in priming solution on blood viscosity under hypothermic conditions.
作者信息
Sapmaz Ismail, Manduz Sinasi, Sanri Umut S, Karahan Oguz, Dogan Kasim
机构信息
Sivas Numune Hastanesi, Sivas, Turkey.
出版信息
Cardiovasc J Afr. 2009 May-Jun;20(3):168-9.
OBJECTIVE
Albumin is used routinely as a plasma volume expander in cardiopulmonary bypass operations. The effect of two different concentrations of albumin in Ringer's lactate on blood viscosity was explored in this study.
METHODS
Ten healthy volunteers (all male) were included in the study, based on their haematocrit levels (42.6 +/- 0.96). Using a heparinised 50-ml syringe, 40 cm(3) of blood were drawn from the antecubital veins of fasting volunteers. Six ml of blood were haemodiluted with 2 ml of albumin (20%), 2 ml of Ringer's lactate containing albumin (1.3%), and 2 ml of Ringer's lactate, in order to simulate cardiopulmonary bypass conditions. Test tubes with the solutions were placed in a 15 degrees C water bath for 25 minutes. Viscosity was measured in the haemodiluted blood samples using an Ostwald viscometer. Relative viscosities of samples were assessed with SPSS software and the ANOVA test.
RESULTS
The mean relative viscosity of Ringer's lactate was 4.19 (+/- 0.49), that of Ringer's lactate with 1.3% albumin was 4.30 (+/- 0.31), and of 20% albumin was 7.32 (+/- 0.71). The relative viscosity of Ringer's lactate and Ringer's lactate with 1.3% albumin were statistically similar, but that of 20% albumin was higher than the Ringer's lactate and Ringer's lactate with 1.3% albumin.
CONCLUSION
Albumin is used as a plasma volume expander in priming solutions for cardiopulmonary bypass operations, but its effect on blood viscosity depends on the concentration of albumin used.
目的
白蛋白在心肺转流手术中常被用作血浆容量扩充剂。本研究探讨了两种不同浓度的白蛋白加入乳酸林格液中对血液黏度的影响。
方法
基于血细胞比容水平（42.6±0.96），10名健康志愿者（均为男性）被纳入研究。使用一支肝素化的50毫升注射器，从空腹志愿者的肘前静脉抽取40立方厘米血液。为模拟心肺转流情况，分别用2毫升白蛋白（20%）、2毫升含白蛋白的乳酸林格液（1.3%）和2毫升乳酸林格液对6毫升血液进行血液稀释。装有这些溶液的试管置于15℃水浴中25分钟。使用奥氏黏度计测量血液稀释样本的黏度。样本的相对黏度用SPSS软件和方差分析进行评估。
结果
乳酸林格液的平均相对黏度为4.19（±0.49），含1.3%白蛋白的乳酸林格液为4.30（±0.31），20%白蛋白为7.32（±0.71）。乳酸林格液和含1.3%白蛋白的乳酸林格液的相对黏度在统计学上相似，但20%白蛋白的相对黏度高于乳酸林格液和含1.3%白蛋白的乳酸林格液。
结论
白蛋白在心肺转流手术的预充液中用作血浆容量扩充剂，但其对血液黏度的影响取决于所用白蛋白的浓度。
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