Medical-Surgical Intensive Care Unit, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro 20230-130 Brazil.
J Crit Care. 2009 Dec;24(4):556-62. doi: 10.1016/j.jcrc.2009.04.004. Epub 2009 Jul 3.
The aim of the study was to characterize the practices of Brazilian ICU physicians toward sedation and delirium.
A cross-sectional survey was conducted among a convenience sample of critical care physicians between April and June 2008.
One thousand fifteen critical care physicians responded. Sedation scoring systems were used by 893 (88.3%) of the respondents. The Ramsay and Richmond Agitation-Sedation Scale were used by 81.9% and 6.8% of the respondents, respectively. Most respondents did not discuss sedation targets (62.8%) or practice daily sedative interruption (68.3%) in most patients. More than half of the respondents (52.7%) used a sedation protocol, and the most used sedatives were midazolam (97.8%), fentanyl (91.5%), and propofol (55%). A significant rate of the respondents (42.7%) estimated that more than 25% of patients under mechanical ventilation have delirium, but 53.5% occasionally assessed patients for delirium. Thirteen percent used specific delirium scales, with the Confusion Assessment Method for intensive care unit (ICU) being the most applied. Delirium was often treated with haloperidol (88.1%); however, atypical antipsychotics (36.3%) and benzodiazepines (42.3%) were also used.
Despite the recent advances in knowledge of sedation and delirium, most of them are still not translated into clinical practice. Significant variation in practice is observed among ICU physicians and represents a potential target for future research and educational interventions.
本研究旨在描述巴西 ICU 医师镇静和谵妄管理的实践情况。
2008 年 4 月至 6 月,采用便利抽样法对重症监护医师进行了横断面调查。
1015 名重症监护医师做出了回应。893 名(88.3%)受访者使用了镇静评分系统。分别有 81.9%和 6.8%的受访者使用 Ramsay 和 Richmond 躁动-镇静量表。大多数受访者未讨论镇静目标(62.8%)或在大多数患者中实施每日镇静中断(68.3%)。超过一半的受访者(52.7%)使用镇静方案,最常用的镇静剂为咪达唑仑(97.8%)、芬太尼(91.5%)和丙泊酚(55%)。相当比例的受访者(42.7%)估计,超过 25%的机械通气患者存在谵妄,但只有 53.5%的受访者偶尔会评估患者是否存在谵妄。13%的受访者使用了特定的谵妄量表,其中以 ICU 意识模糊评估法(CAM-ICU)的应用最广泛。谵妄常采用氟哌啶醇(88.1%)治疗;但也使用了非典型抗精神病药(36.3%)和苯二氮䓬类药物(42.3%)。
尽管镇静和谵妄相关知识有了最新进展,但大多数知识仍未转化为临床实践。观察到 ICU 医师的实践存在显著差异,这是未来研究和教育干预的潜在目标。