Department of Biomedical Sciences, University of Catania, Italy.
Crit Rev Oncol Hematol. 2010 Apr;74(1):40-60. doi: 10.1016/j.critrevonc.2009.06.002. Epub 2009 Jul 4.
The increased incidence of malignancies in elderly patients living in industrialized countries has led to both identify the causes that alter the normal homeostatic balance in elderly and designate the specific treatments. The progressive decline of the immune system (immunosenescence) involving cellular and molecular alterations impact both innate and adaptive immunity. The immunosenescence leads to increased incidence of infectious diseases morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. Here, we summarize the knowledge on the major changes in the immune system associated with aging in primary lymphoid organs as well as a description of molecular mechanisms, and the impact on cancer development.
随着工业化国家老年人群恶性肿瘤发病率的增加，人们不仅致力于识别改变老年人群正常体内平衡的原因，还致力于确定特定的治疗方法。包括细胞和分子改变在内的免疫系统的逐渐衰退（免疫衰老）会影响固有免疫和适应性免疫。免疫衰老导致传染病发病率和死亡率增加，以及其他免疫疾病（如自身免疫、癌症和炎症性疾病）的发生率增加。在这里，我们总结了与初级淋巴器官衰老相关的免疫系统的主要变化，以及对癌症发展的影响的分子机制方面的知识。
