EMR Section, Australian Radiation Protection and Nuclear Safety Agency, Victoria, Australia.
Occup Med (Lond). 2009 Sep;59(6):437-9. doi: 10.1093/occmed/kqp096. Epub 2009 Jul 3.
Our previous investigation of occupational exposure to ionizing radiation using a Finnish job-exposure matrix (JEM) showed no association with non-Hodgkin lymphoma (NHL) in a population-based case-control study in Australia.
To determine whether occupational exposure to ionizing radiation assessed using an Australian JEM is associated with NHL.
We analysed 694 NHL cases, first diagnosed between 1 January 2000 and 31 August 2001 and 694 controls from south-eastern Australia, matched by age, sex and region of residence. A detailed occupational history was obtained using a lifetime calendar and a telephone interview. Exposure to radiation was assessed using the ionizing radiation component of an Australian JEM. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from logistic regression models that included the matching variables as covariates.
The OR for workers ever exposed to ionizing radiation was 0.86 (95% CI = 0.52-1.40). Dividing the subjects into tertiles of exposure also found ORs that were close to or below the null for each exposure group.
The application of an Australian JEM did not provide evidence for an association between NHL and occupational exposure to ionizing radiation and is consistent with previous analyses.
我们之前使用芬兰职业暴露矩阵（JEM）对职业电离辐射暴露进行的调查在澳大利亚基于人群的病例对照研究中未发现与非霍奇金淋巴瘤（NHL）有关。
确定使用澳大利亚 JEM 评估的职业电离辐射暴露是否与 NHL 相关。
我们分析了 694 例 NHL 病例，这些病例均于 2000 年 1 月 1 日至 2001 年 8 月 31 日期间在澳大利亚东南部首次诊断，与年龄、性别和居住地区相匹配的 694 例对照。通过终生日历和电话访谈获得详细的职业史。使用澳大利亚 JEM 的电离辐射部分评估辐射暴露。使用包含匹配变量作为协变量的逻辑回归模型计算比值比（OR）和 95%置信区间（CI）。
曾接触电离辐射的工人的 OR 为 0.86（95%CI=0.52-1.40）。将受试者分为暴露三分位数组，也发现每个暴露组的 OR 接近或低于零。
澳大利亚 JEM 的应用并未提供职业电离辐射暴露与 NHL 之间存在关联的证据，与之前的分析一致。
