Karipidis Ken K, Benke Geza, Sim Malcolm R, Kauppinen Timo, Kricker Anne, Hughes Ann Maree, Grulich Andrew E, Vajdic Claire M, Kaldor John, Armstrong Bruce, Fritschi Lin
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Int Arch Occup Environ Health. 2007 Aug;80(8):663-70. doi: 10.1007/s00420-007-0177-0. Epub 2007 Mar 2.
To investigate the association between occupational exposure to ionizing, ultraviolet (UV), radiofrequency (RF) and extremely low frequency (ELF) radiation and risk of developing non-Hodgkin lymphoma (NHL) in a population-based case-control study.
The study population consisted of 694 NHL cases, first diagnosed between 1 January 2000 and 31 August 2001, and 694 controls from two regions in Australia, matched by age, sex and region of residence. A detailed occupation history was first obtained using a lifetime calendar and a telephone interview. Exposure to radiation was then assessed using a Finnish job-exposure matrix (FINJEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from logistic regression models that included the matching variables as covariates.
For ionizing radiation, the ORs were close to unity. For UV and ELF radiation, the highest exposed group of workers had ORs of 1.32 (95% CI=0.96-1.81) and 1.25 (95% CI=0.91-1.72), respectively. For UV radiation there was a positive dose-response when exposure was lagged by 5 and 10 years (P for trend 0.04 for both lag periods). Workers in the upper tertile of exposure for RF radiation had an OR of 3.15 (95% CI=0.63-15.87), but the estimate was based on very small numbers.
Our results do not provide support for an association between NHL and occupational exposure to ionizing or ELF radiation. For UV radiation, our findings are consistent with a weak positive association. Further investigation focusing on UV and RF radiation and NHL is required.
在一项基于人群的病例对照研究中，调查职业性接触电离辐射、紫外线（UV）、射频（RF）和极低频（ELF）辐射与患非霍奇金淋巴瘤（NHL）风险之间的关联。
研究人群包括694例于2000年1月1日至2001年8月31日首次确诊的NHL病例，以及来自澳大利亚两个地区的694名对照，根据年龄、性别和居住地区进行匹配。首先使用终身日历和电话访谈获取详细的职业史。然后使用芬兰工作暴露矩阵（FINJEM）评估辐射暴露情况。通过将匹配变量作为协变量纳入的逻辑回归模型计算比值比（OR）和95%置信区间（CI）。
对于电离辐射，OR接近1。对于紫外线和极低频辐射，暴露程度最高的工人群体的OR分别为1.32（95%CI = 0.96 - 1.81）和1.25（95%CI = 0.91 - 1.72）。对于紫外线辐射，当暴露滞后5年和10年时存在正剂量反应（两个滞后时期的趋势P均为0.04）。射频辐射暴露处于上三分位数的工人的OR为3.15（95%CI = 0.63 - 15.87），但该估计基于非常少的数量。
我们的结果不支持NHL与职业性接触电离辐射或极低频辐射之间存在关联。对于紫外线辐射，我们的发现与弱正相关一致。需要针对紫外线和射频辐射与NHL进行进一步调查。
