Tompkins Connie L, Cefalu William, Ravussin Eric, Goran Michael, Soros Arlette, Volaufova Julia, Vargas Alfonso, Sothern Melinda S
Louisiana State University School of Public Health, New Orleans, LA 70112, USA.
Int J Pediatr Obes. 2010;5(1):51-5. doi: 10.3109/17477160903055937.
Insulin sensitivity was determined by FSIVGTT.
FSIVGTT was attempted in a total of 22 study participants. Insulin sensitivity was successfully assessed in 15 study participants (8 males, 7 females, 10 Caucasian, 4 African American, 1 Pacific Islander, age range 7-9 years). Mean insulin sensitivity was 15.1+/-9.8 (mmicro/l)(-1) min(-1) range 4.4-43.2 (mmicro/l)(-1) min(-1). However, seven study participants experienced mild adverse events of hypoglycemia. Several addendums were made to the FSIVGTT protocol to ensure study participants' comfort and safety, and to decrease the frequency of mild adverse events and increase test completion rates.
Addendums made to FSIVGTT protocol allowed successful completion of FSIVGTT in 15 (68%) of the 22 children. These results demonstrate that FSIVGTT is challenging, yet feasible in healthy lean and obese pre-pubertal children.
1）报告在健康体重、超重和肥胖的青春期前儿童中完成180分钟频繁取样静脉葡萄糖耐量试验（FSIVGTT）的可行性，以及2）描述在实施附录以降低轻度不良事件发生率并提高试验完成率后最终确定的FSIVGTT方案。
通过FSIVGTT测定胰岛素敏感性。
共对22名研究参与者进行了FSIVGTT尝试。15名研究参与者（8名男性，7名女性，10名白种人，4名非裔美国人，1名太平洋岛民，年龄范围7 - 9岁）成功评估了胰岛素敏感性。平均胰岛素敏感性为15.1±9.8（微摩尔/升）⁻¹分钟⁻¹，范围为4.4 - 43.2（微摩尔/升）⁻¹分钟⁻¹。然而，7名研究参与者经历了低血糖的轻度不良事件。对FSIVGTT方案进行了多项附录修订，以确保研究参与者的舒适度和安全性，并降低轻度不良事件的发生率，提高试验完成率。
对FSIVGTT方案的附录修订使得22名儿童中有15名（68%）成功完成了FSIVGTT。这些结果表明，FSIVGTT具有挑战性，但在健康的瘦型和肥胖青春期前儿童中是可行的。
