Iida Hiroshi, Inamori Masahiko, Akimoto Keiko, Mawatari Hironori, Endo Hiroki, Nozaki Yuichi, Akiyama Tomoyuki, Ikeda Tamon, Sakamoto Yasunari, Fujita Koji, Yoneda Kyoko, Takahashi Hirokazu, Yoneda Masato, Goto Ayumu, Abe Yasunobu, Kobayashi Noritoshi, Kirikoshi Hiroyuki, Kubota Kensuke, Saito Satoru, Nakajima Atsushi
Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama Kanagawa, 236-0004, Japan.
Hepatogastroenterology. 2009 Mar-Apr;56(90):551-4.
BACKGROUND/AIMS: The ideal medication for treatment of acid related diseases should have a rapid onset of action to promote hemostasis. The aim of our study was to investigate the inhibitory effects on gastric acid secretion after single intravenous administrations of lansoprazole 30 mg and famotidine 20 mg.
Twelve Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after single intravenous administration of lansoprazole 30 mg or famotidine 20 mg.
The average pH during the 4-hour period after administration of famotidine was higher than after lansoprazole (median: 5.15 versus 3.55, respectively; p = 0.0376). During the 4-hour study period, famotidine 20 mg provided a longer duration of pH > 3, 3.5, 4, 5, 6 and 7, compared to lansoprazole 30 mg (median: 73.6% versus 57.0%; p = 0.0414, 66.8% versus 47.8%; p = 0.0281, 60.8% versus 38.8%; p = 0.0150, 55.7% versus 29.7%; p = 0.0281, 45.0% versus 23.1%; p = 0.0414 and 23.9% versus 3.65%; p = 0.0076).
In Helicobacter pylori-negative healthy male subjects, an intravenous dose of famotidine 20 mg more rapidly increases intragastric pH than lansoprazole 30 mg.
背景/目的：治疗酸相关性疾病的理想药物应具有快速起效以促进止血的作用。本研究的目的是调查单次静脉注射30毫克兰索拉唑和20毫克法莫替丁后对胃酸分泌的抑制作用。
12名幽门螺杆菌阴性的男性受试者参与了这项随机、双向交叉研究。单次静脉注射30毫克兰索拉唑或20毫克法莫替丁后，连续4小时监测胃内pH值。
注射法莫替丁后4小时内的平均pH值高于注射兰索拉唑后（中位数：分别为5.15和3.55；p = 0.0376）。在4小时的研究期间，与30毫克兰索拉唑相比，20毫克法莫替丁使pH值>3、3.5、4、5、6和7的持续时间更长（中位数：73.6%对57.0%；p = 0.0414，66.8%对47.8%；p = 0.0281，60.8%对38.8%；p = 0.0150，55.7%对29.7%；p = 0.0281，45.0%对23.1%；p = 0.0414，23.9%对3.65%；p = 0.0076）。
在幽门螺杆菌阴性的健康男性受试者中，静脉注射20毫克法莫替丁比30毫克兰索拉唑能更快提高胃内pH值。
