Abe Yasunobu, Inamori Masahiko, Togawa Jun-Ichi, Kikuchi Taisuke, Muramatsu Kenichi, Chiguchi Gaku, Kawamura Harunobu, Kobayashi Noritoshi, Kirikoshi Hiroyuki, Sakaguchi Takashi, Takamura Tomoo, Nakajima Atsushi, Ueno Norio, Sekihara Hisahiko
The Third Department of Internal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
J Gastroenterol. 2004 Jan;39(1):21-5. doi: 10.1007/s00535-003-1240-6.
The ideal medication for the treatment of acid-related diseases, for example, hemorrhagic ulcers and stress-related gastric bleeding, should have a rapid onset of action to promote hemostasis and alleviate symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion after single intravenous administrations of omeprazole 20mg and famotidine 20 mg.
Ten healthy Helicobacter pylori-negative male subjects participated in this randomized, double-masked, two-way crossover study. Intragastric pH was monitored continuously for 4 h after a single intravenous administration of omeprazole 20 mg and after a single intravenous administration of famotidine 20 mg. The administration of the two agents was separated by a 7-day washout period.
In all ten subjects, the length of time that intragastric pH remained over 3, during the 0- to 3- and 0- to 4-h study periods, was greater after famotidine treatment than after treatment with omeprazole, and famotidine increased the average pH during the 0 to 3- and 0 to 4-h study periods significantly more than omeprazole did. During the 4-h study period, famotidine provided a longer duration of pH of more than 2, 3, 3.5, 4, 5, 6, and 7, compared to omeprazole.
In Helicobacter pylori-negative healthy male subjects, an intravenous dose of 20 mg famotidine increased intragastric pH more rapidly than intravenous omeprazole 20 mg.
治疗酸相关性疾病，如出血性溃疡和应激性胃出血的理想药物应起效迅速，以促进止血并缓解症状。我们研究的目的是调查单次静脉注射20毫克奥美拉唑和20毫克法莫替丁后对胃酸分泌的抑制作用。
十名幽门螺杆菌阴性的健康男性受试者参与了这项随机、双盲、双向交叉研究。在单次静脉注射20毫克奥美拉唑后和单次静脉注射20毫克法莫替丁后，连续监测胃内pH值4小时。两种药物的给药间隔7天的洗脱期。
在所有十名受试者中，在0至3小时和0至4小时的研究期间，胃内pH值保持在3以上的时间，法莫替丁治疗后比奥美拉唑治疗后更长，并且法莫替丁在0至3小时和0至4小时的研究期间使平均pH值升高的幅度明显大于奥美拉唑。在4小时的研究期间，与奥美拉唑相比，法莫替丁使pH值高于2、3、3.5、4、5、6和7的持续时间更长。
在幽门螺杆菌阴性的健康男性受试者中，静脉注射2毫克法莫替丁比静脉注射20毫克奥美拉唑能更快地提高胃内pH值。
