Department of Gastroenterology, Changhai Hospital, 2nd Military Medical University, Shanghai, China.
Med Sci Monit. 2012 Feb;18(2):CR125-130. doi: 10.12659/msm.882468.
Until now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity.
MATERIAL/METHODS: Helicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period.
Twenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41 ± 0.14 vs. 5.49 ± 0.13, P=0.0003) and day 5 (7.09 ± 0.07 vs. 6.64 ± 0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12 ± 4.55% vs. 62.28 ± 4.15%, P=0.0012; pH >6, 62.12 ± 4.12% vs. 47.25 ± 3.76%, P=0.0216) and pH >6 on day 5 (76.79 ± 3.77% vs. 58.20 ± 3.77%, P=0.0025).
Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole.
目前尚无研究直接比较静脉给予兰索拉唑和泮托拉唑对胃内酸度的影响。本研究旨在比较静脉给予兰索拉唑（30mg）和泮托拉唑（40mg）对胃内酸度的影响。
材料/方法：本研究为开放标签、随机、两周期、单中心研究，纳入了幽门螺杆菌阴性的健康志愿者。兰索拉唑 30mg 或泮托拉唑 40mg 每日静脉给药 2 次，连续 5 天，洗脱期至少 14 天。在每个给药期的第 1 天和第 5 天连续监测 24 小时胃内 pH 值。
25 名志愿者完成了 2 个给药期。与泮托拉唑相比，兰索拉唑治疗的受试者在第 1 天（6.41±0.14 vs. 5.49±0.13，P=0.0003）和第 5 天（7.09±0.07 vs. 6.64±0.07，P=0.0002）的胃内 pH 值更高。与泮托拉唑相比，兰索拉唑治疗的受试者第 1 天胃内 pH 值＞4 和 pH 值＞6 的时间百分比更高（pH 值＞4，87.12±4.55% vs. 62.28±4.15%，P=0.0012；pH 值＞6，62.12±4.12% vs. 47.25±3.76%，P=0.0216）和第 5 天胃内 pH 值＞6 的时间百分比更高（76.79±3.77% vs. 58.20±3.77%，P=0.0025）。
静脉给予兰索拉唑对胃内酸度的抑制作用较静脉给予泮托拉唑更持久、更强。
