University of Western Ontario, London, Ontario, Canada.
J Cogn Neurosci. 2010 Jul;22(7):1493-503. doi: 10.1162/jocn.2009.21281.
When exposed to novel dynamical conditions (e.g., externally imposed forces), neurologically intact subjects easily adjust motor commands on the basis of their own reaching errors. Subjects can also benefit from visual observation of others' kinematic errors. Here, using fMRI, we scanned subjects watching movies depicting another person learning to reach in a novel dynamic environment created by a robotic device. Passive observation of reaching movements (whether or not they were perturbed by the robot) was associated with increased activation in fronto-parietal regions that are normally recruited in active reaching. We found significant clusters in parieto-occipital cortex, intraparietal sulcus, as well as in dorsal premotor cortex. Moreover, it appeared that part of the network that has been shown to be engaged in processing self-generated reach error is also involved in observing reach errors committed by others. Specifically, activity in left intraparietal sulcus and left dorsal premotor cortex, as well as in right cerebellar cortex, was modulated by the amplitude of observed kinematic errors.
当暴露于新的动力条件（例如，外部施加的力）时，神经完整的受试者可以轻松地根据自己的伸手错误来调整运动指令。受试者还可以受益于观察他人运动学错误的视觉效果。在这里，我们使用 fMRI 扫描了观看电影的受试者，这些电影描绘了另一个人在由机器人设备创建的新颖动态环境中学习伸手的情况。被动观察伸手动作（无论机器人是否对其进行干扰）都会导致额顶叶区域的激活增加，这些区域通常在主动伸手时被募集。我们在顶枕叶皮层、内顶叶沟以及背侧运动前皮层中发现了显著的聚类。此外，似乎参与处理自我产生的伸手错误的网络的一部分也参与了观察他人犯的伸手错误。具体而言，左顶内沟和左背侧运动前皮层以及右小脑皮层的活动会受到观察到的运动学错误幅度的调节。
