Koike R, Yoshida S, Takahashi H
Division of Internal Medicine, Asahi General Hospital.
Arerugi. 1991 Sep;40(9):1232-8.
We experienced a case of idiopathic hypereosinophilic syndrome (HES) associated with pulmonary infarction. The case was a 22-year-old woman with marked eosinophilia (16835/microliters) and peripheral edema and cyanosis. During hospitalization, she suddenly developed lower right chest pain, and infiltrative lesions with pleural effusions in the right lung were prominent. A diagnosis of pulmonary infarction was made after perfusion scan and angiography of the lung. Lupus anticoagulant was found to be positive and a transient increase of anti-cardiolipin antibody slightly in her serum was also observed. Recurrent thrombosis is known to be complicated by HES but its mechanism remains to be clarified. There has also been no study reported in the literature on the role of lupus anticoagulant in this process; its possible role in this patient is discussed.
我们遇到一例与肺梗死相关的特发性嗜酸性粒细胞增多综合征（HES）。该病例为一名22岁女性，有明显的嗜酸性粒细胞增多（16835/微升）以及外周水肿和发绀。住院期间，她突然出现右下胸痛，右肺出现伴有胸腔积液的浸润性病变。经肺部灌注扫描和血管造影后诊断为肺梗死。发现狼疮抗凝物呈阳性，同时在她的血清中也观察到抗心磷脂抗体略有短暂升高。已知复发性血栓形成是HES的并发症，但其机制仍有待阐明。文献中也没有关于狼疮抗凝物在此过程中作用的研究报道；本文讨论了其在该患者中可能发挥的作用。
