Sohn D R, Shin S G, Park C W, Kusaka M, Chiba K, Ishizaki T
Department of Pharmacology, Gyeong-Sang National University, College of Medicine, Chinju, Korea.
Br J Clin Pharmacol. 1991 Oct;32(4):504-7. doi: 10.1111/j.1365-2125.1991.tb03939.x.
We examined metoprolol oxidation capacity in 218 unrelated, healthy Korean subjects using the 8 h urinary metabolic ratio (MR) of metoprolol to alpha-hydroxymetoprolol after an oral dose of 100 mg metoprolol tartrate. The results were compared with those from 295 Japanese and 107 mainland Chinese whose metoprolol oxidation capacities were assessed in a similar manner. The frequency of occurrence of poor metabolisers (PMs) was 0.5% (1/218) in the Korean, 0.7% (2/295) in the Japanese and 0% in the Chinese population. However, the respective mean (+/- s.d.) MRs (0.84 +/- 1.14 and 0.87 +/- 0.90) in the Korean and Japanese extensive metabolisers (EMs) were significantly (P less than 0.001) less than that in the Chinese EMs (2.81 +/- 2.35), and the mode of the distribution histogram and the probit plot of data for Chinese EMs were shifted to the right compared with those for Korean and Japanese EMs. The results indicate that Koreans, like Japanese and mainland Chinese, have a much lower frequency of the PM phenotype of debrisoquine/sparteine-type oxidation compared with that reported for Caucasian populations. Chinese EMs appear to have a lower capacity to metabolise metoprolol to alpha-hydroxymetoprolol compared with Korean or Japanese EMs.
我们对218名无亲缘关系的健康韩国受试者进行了美托洛尔氧化能力检测，方法是口服100毫克酒石酸美托洛尔后，测定8小时尿液中美托洛尔与α-羟基美托洛尔的代谢比值（MR）。将结果与295名日本人和107名中国大陆人的结果进行比较，这些人的美托洛尔氧化能力也是用类似方法评估的。韩国人群中慢代谢者（PMs）的出现频率为0.5%（1/218），日本人群中为0.7%（2/295），中国人群中为0%。然而，韩国和日本的快代谢者（EMs）各自的平均（±标准差）MRs（分别为0.84±1.14和0.87±0.90）显著低于（P<0.001）中国快代谢者的MRs（2.81±2.35），并且与韩国和日本快代谢者相比，中国快代谢者的数据分布直方图模式和概率单位图向右偏移。结果表明，与白种人群相比，韩国人与日本人和中国大陆人一样，去甲异喹胍/鹰爪豆碱型氧化的PM表型出现频率要低得多。与韩国或日本快代谢者相比，中国快代谢者将美托洛尔代谢为α-羟基美托洛尔的能力似乎较低。
