Martínez-Ríos Marco Antonio, Peña-Duque Marco Antonio, Fragoso José Manuel, Delgadillo-Rodríguez Hilda, Rodríguez-Pérez José Manuel, Miranda-Malpica Emma, Cruz-Robles David, Cavazos-Quero María Magdalena, Rodríguez-Lobato Luis Gerardo, Vargas-Alarcón Gilberto
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Biochem Genet. 2009 Oct;47(9-10):707-16. doi: 10.1007/s10528-009-9268-9. Epub 2009 Jul 8.
To test for an association with risk for restenosis after coronary stent placement, the TNF-alpha and IL-10 polymorphisms were analyzed by 5' exonuclease TaqMan assays in 162 patients who initially underwent coronary stenting. Analysis of basal and procedure coronary angiographies revealed a higher proportion of restenosis in lesions treated with bare metal stents compared with those treated with drug-eluting stents (P < 0.001). Distribution of TNF-alpha genotypes was similar in patients with and without restenosis. The IL-10 polymorphisms showed a moderate protective trend of the -819 TT genotype against restenosis when the lesions were analyzed (P = 0.071, OR = 0.471). Multivariate analysis confirmed a protective role for drug-eluting stents (P < 0.001, OR = 0.199) and the -819 TT genotype (P = 0.037, OR = 0.391). These results suggest the IL-10 -819 TT genotype has a protective role against in-stent restenosis.
