Ohta Kouichi, Sano Kenji, Imai Hiroki, Kikuchi Takanobu
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
Ocul Immunol Inflamm. 2009 May-Jun;17(3):142-7. doi: 10.1080/09273940802702553.
The authors investigate the efficacy of using the cytokine levels and clonal heavy-chain immunoglobulin (IgH) gene rearrangements in the vitreous as adjunctive tools to diagnose intraocular lymphoma (IOL).
The IL-10 and IL-6 levels and IgH gene rearrangements were analyzed in vitreous samples from 8 cases of IOL and in 14 uveitis patients.
The level of IL-10 with an IL-10/IL-6 ratio > 1 was significantly higher in all eyes with IOL. B-cell monoclonality was detected in only 5 of 8 eyes with IOL.
The measurements of the levels of cytokines are valuable as a reliable biomarker.
作者研究使用玻璃体内细胞因子水平和克隆性重链免疫球蛋白（IgH）基因重排作为辅助手段诊断眼内淋巴瘤（IOL）的疗效。
分析了8例IOL患者和14例葡萄膜炎患者玻璃体液样本中的IL-10和IL-6水平以及IgH基因重排情况。
所有IOL患眼中，IL-10水平及IL-10/IL-6比值>1者显著更高。8例IOL患眼中仅5例检测到B细胞单克隆性。
细胞因子水平测定作为一种可靠的生物标志物具有重要价值。
