Bullon P, Morillo J M, Ramirez-Tortosa M C, Quiles J L, Newman H N, Battino M
Deptartment of Periodontology, Dental School, University of Sevilla, Spain.
J Dent Res. 2009 Jun;88(6):503-18. doi: 10.1177/0022034509337479.
A review of pathological mechanisms that can explain the relationship between periodontitis and cardiovascular disease (CVD) is necessary to improve the management of both conditions. Metabolic syndrome is a combination of obesity, hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia, and dyslipidemia. All these have been examined in recent years in terms of their relationship to periodontitis. Reviewed data indicate an association between some of them (body mass index, high-density lipoprotein-cholesterol [HDL-C], triglycerides, high blood pressure, among others) and periodontitis. Oxidative stress may act as a potential common link to explain relationships between each component of metabolic syndrome and periodontitis. Both conditions show increased serum levels of products derived from oxidative damage, with a pro-inflammatory state likely influencing each other bidirectionally. Adipocytokines might modulate the oxidant/anti-oxidant balance in this relationship.
为了更好地管理牙周炎和心血管疾病（CVD）这两种病症，有必要回顾一下能够解释它们之间关系的病理机制。代谢综合征是肥胖、高血压、糖耐量受损或糖尿病、高胰岛素血症和血脂异常的组合。近年来，所有这些因素与牙周炎的关系都得到了研究。综述数据表明，其中一些因素（体重指数、高密度脂蛋白胆固醇[HDL-C]、甘油三酯、高血压等）与牙周炎之间存在关联。氧化应激可能是解释代谢综合征各组分与牙周炎之间关系的潜在共同环节。这两种病症都表现出氧化损伤产物的血清水平升高，炎症前状态可能会双向相互影响。在这种关系中，脂肪细胞因子可能会调节氧化/抗氧化平衡。
