Evangelopoulos Angelos A, Vallianou Natalia G, Panagiotakos Demosthenes B, Georgiou Aikaterini, Zacharias Georgios A, Alevra Andri N, Zalokosta Georgia J, Vogiatzakis Evangelos D, Avgerinos Peter C
Department of Microbiology, Polykliniki General Hospital, 10552 Athens, Greece.
Nutr Res. 2008 Oct;28(10):659-63. doi: 10.1016/j.nutres.2008.07.001.
Metabolic syndrome has been defined as the presence of abdominal obesity combined with 2 of the following factors: hypertension, dyslipidemia, and impaired glucose tolerance, or diabetes mellitus. Magnesium is an essential cofactor for more than 300 enzymes involved in carbohydrate and lipid metabolism. In this study, we enrolled 117 consecutive overweight and obese patients and we measured serum magnesium levels together with fasting serum glucose, high-density lipoprotein cholesterol, and triacylglycerols. A strong inverse relationship between magnesium levels in serum and the presence of metabolic syndrome was noticed. Moreover, magnesium levels decreased as the number of components of metabolic syndrome increased. Also, there is an inverse relationship between serum magnesium levels and high-sensitivity C-reactive protein. We concluded that decreased levels of serum magnesium are associated with increased risk for metabolic syndrome, perhaps by a low-grade inflammation process.
代谢综合征的定义为存在腹部肥胖，并伴有以下因素中的两项：高血压、血脂异常、糖耐量受损或糖尿病。镁是参与碳水化合物和脂质代谢的300多种酶的必需辅助因子。在本研究中，我们连续纳入了117例超重和肥胖患者，并测量了血清镁水平以及空腹血糖、高密度脂蛋白胆固醇和甘油三酯。我们注意到血清镁水平与代谢综合征的存在之间存在强烈的负相关关系。此外，随着代谢综合征组成成分数量的增加，镁水平降低。而且，血清镁水平与高敏C反应蛋白之间也存在负相关关系。我们得出结论，血清镁水平降低与代谢综合征风险增加相关，可能是通过低度炎症过程导致的。
