Giannakopoulos Bill, Krilis Steven A
Department of Immunology, Allergy and Infectious Diseases, St George Hospital, Kogarah, Australia.
Blood. 2009 Sep 3;114(10):2020-30. doi: 10.1182/blood-2009-05-220756. Epub 2009 Jul 8.
This article discusses how we approach medical decision making in the treatment of the various facets of the antiphospholipid syndrome (APS), including secondary prophylaxis in the setting of venous and arterial thrombosis, as well as treatment for the prevention of recurrent miscarriages and fetal death. The role of primary thromboprophylaxis is also discussed in depth. Great emphasis is given to incorporating the most up-to-date and relevant evidence base both from the APS literature, and from large, recent, randomized controlled trials (RCTs) of primary and secondary thrombotic prophylaxis in the general population setting (ie, the population that has not been specifically investigated for APS).
本文讨论了我们在治疗抗磷脂综合征（APS）各个方面时如何进行医学决策，包括静脉和动脉血栓形成情况下的二级预防，以及预防反复流产和胎儿死亡的治疗。还深入讨论了一级血栓预防的作用。我们非常重视纳入来自APS文献以及近期在一般人群（即未专门针对APS进行研究的人群）中进行的一级和二级血栓预防大型随机对照试验（RCT）的最新且相关的证据基础。
