Reuss Reinhard, Reuter Iris, Jauss Marek, Fischer Falko, Muller Silke C, Stolz Erwin
Department of Neurology, Justus Liebig University Giessen, Giessen, Germany.
Pharmacology. 2009;84(2):91-2. doi: 10.1159/000227773. Epub 2009 Jul 8.
The muscle-relaxing 5-HT(2) receptor antagonist cyclobenzaprine is structurally closely related to amitriptyline. It is widely used to treat patients presenting with back pain and fibromyalgia. Very rarely cyclobenzaprine toxicity can result in extrapyramidal symptoms, but occurrence of torticollis has not been reported so far. We report on a patient presenting with torticollis and myoclonic movements after treatment with cyclobenzaprine, who was successfully treated with intravenous biperiden. This case might be additional evidence for the necessity of appropriate dosage in case of liver impairment. Secondly there are possibly consequences as regards the therapy of motor side effects.
肌肉松弛剂5-羟色胺（5-HT）2受体拮抗剂环苯扎林在结构上与阿米替林密切相关。它被广泛用于治疗背痛和纤维肌痛患者。环苯扎林中毒非常罕见地会导致锥体外系症状，但迄今为止尚未有斜颈发生的报道。我们报告了1例在用环苯扎林治疗后出现斜颈和肌阵挛运动的患者，该患者经静脉注射安坦成功治疗。该病例可能是肝损伤时适当用药必要性的又一证据。其次，在运动副作用的治疗方面可能存在后果。
