Department of Urology, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey.
Int Urol Nephrol. 2010 Mar;42(1):47-51. doi: 10.1007/s11255-009-9605-2. Epub 2009 Jul 10.
In the present study, the relationship between serum/seminal plasma and serum FSH and seminal parameters was evaluated in adults and adolescent varicocele patients and compared with normal fertile cases.
A total of 50 adult patients with varicocele (Group-1) and 50 adolescents with varicocele (Group-2) were enrolled into the study. Fifty fertile cases without any scrotal pathology were accepted as control group (Group-3). Serum gonadotropin, sex steroids and serum and seminal plasma inhibin-B levels were measured, and semen analysis was performed after 2 and 5 days of sexual abstinence. All parameters were compared among three groups by using one-way ANOVA test.
There were statistically significant differences among three groups on seminal parameters due to disturbed spermatogenesis in patients with varicocele (P < 0.05). However, there were not statistical differences between serum and seminal plasma Inhibin-B levels among groups. In varicocele patients, serum inhibin-B levels showed negative and significant correlation only with FSH levels (r = -0.253, P = 0.011). On the contrary, neither serum nor seminal plasma inhibin-B levels showed significant correlation with seminal parameters.
While varicocele affects different mechanisms in the regulation of spermatogenesis in testes, serum and seminal plasma inhibin-B have not any role in decreased spermatogenesis in varicocele.
在本研究中，评估了成年和青少年精索静脉曲张患者的血清/精液浆与血清 FSH 和精液参数之间的关系，并与正常生育病例进行了比较。
共纳入 50 例成年精索静脉曲张患者（第 1 组）和 50 例青少年精索静脉曲张患者（第 2 组）。选择 50 例无阴囊病变的正常生育者作为对照组（第 3 组）。在禁欲 2 天和 5 天后，测量血清促性腺激素、性激素和血清及精液浆抑制素-B 水平，并进行精液分析。采用单因素方差分析比较三组之间的所有参数。
由于精索静脉曲张患者的生精功能受到干扰，三组之间的精液参数存在统计学差异（P < 0.05）。然而，三组之间的血清和精液浆抑制素-B 水平没有统计学差异。在精索静脉曲张患者中，血清抑制素-B 水平仅与 FSH 水平呈负相关且有统计学意义（r = -0.253，P = 0.011）。相反，血清和精液浆抑制素-B 水平均与精液参数无显著相关性。
虽然精索静脉曲张在睾丸生精功能的调节中存在不同的机制，但血清和精液浆抑制素-B 对精索静脉曲张导致的生精减少没有作用。
