The Medical School at the University of Tampere, Tampere, Finland.
Atherosclerosis. 2009 Dec;207(2):466-70. doi: 10.1016/j.atherosclerosis.2009.06.004. Epub 2009 Jun 11.
Inflammatory factors modify the risk of cardiovascular diseases and atherosclerosis. The single base genetic polymorphism in the promoter region of inflammatory cytokine interleukin-6 (IL6 -174 G>C, rs1800795) is associated with the variation of IL-6 production. The aim of this study was to investigate whether IL6 -174 G>C is associated with the risk factors and early markers of atherosclerosis.
As part of Finnish Health 2000 Study, we performed carotid artery ultrasound examinations, IL6 -174 G>C genotyping and cardiovascular risk factor determination for 1334 subjects aged 46-76 years.
In men, serum total cholesterol was higher in IL6 -174 GG (5.70+/-0.88mmol/L) than in the GC (5.51+/-0.98mmol/L) or CC (5.38+/-0.97mmol/L, mean+/-SD, p=0.0059) groups. The same order was seen in LDL-C (GG 3.64+/-0.83mmol/L, GC 3.41+/-0.88mmol/L, CC 3.30+/-0.91mmol/L, p=0.0017). The opposite association was observed with plasma fasting glucose levels (GG 5.93+/-0.97, GC 6.11+/-1.34, CC 6.34+/-1.59mmol/L, p=0.043) and BMI (GG 26.8+/-3.42, GC 27.5+/-4.32, CC 28.0+/-3.81kg/m(2), p=0.027). IL6 -174 allele C homozygous men indicated a trend towards higher systolic blood pressure. IL6 -174 G>C was not associated with carotid artery compliance, intima media thickness or CRP. The effect size of IL6 -174 G>C on cardiovascular risk factors was not significant in women. These results suggest that IL6 -174 G>C modifies the levels of several metabolic risk factors of atherosclerosis in men.
炎症因子可改变心血管疾病和动脉粥样硬化的风险。炎症细胞因子白细胞介素-6（IL-6-174G>C，rs1800795）启动子区域的单碱基遗传多态性与 IL-6 产生的变化有关。本研究旨在探讨 IL6-174G>C 是否与动脉粥样硬化的危险因素和早期标志物有关。
作为芬兰健康 2000 研究的一部分，我们对 1334 名年龄在 46-76 岁的受试者进行了颈动脉超声检查、IL6-174G>C 基因分型和心血管危险因素测定。
在男性中，IL6-174 GG 组（5.70+/-0.88mmol/L）血清总胆固醇高于 GC（5.51+/-0.98mmol/L）或 CC（5.38+/-0.97mmol/L，平均值+/-SD，p=0.0059）组。同样的顺序也见于 LDL-C（GG3.64+/-0.83mmol/L，GC3.41+/-0.88mmol/L，CC3.30+/-0.91mmol/L，p=0.0017）。与空腹血糖水平呈相反的关系（GG5.93+/-0.97，GC6.11+/-1.34，CC6.34+/-1.59mmol/L，p=0.043）和 BMI（GG26.8+/-3.42，GC27.5+/-4.32，CC28.0+/-3.81kg/m2，p=0.027）。IL6-174 等位基因 C 纯合的男性收缩压偏高。IL6-174G>C 与颈动脉顺应性、内膜中层厚度或 CRP 无关。在女性中，IL6-174G>C 对心血管危险因素的影响大小不显著。这些结果表明，IL6-174G>C 改变了男性动脉粥样硬化几种代谢危险因素的水平。
