Gan G-G, Subramaniam R, Lian L-H, Nadarajan Vs
Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Balkan J Med Genet. 2013 Dec;16(2):53-8. doi: 10.2478/bjmg-2013-0032.
Interleukin-6 (IL-6) is one of the cytokines that has been well studied and implicated in many diseases including cancers. The frequency of the IL-6 -174 (G/C) polymorphism had been proven to differ in various populations. Malaysia is a country with three major ethnic populations, Malays, Chinese and Indians. In this study, we proposed to determine the G or C allele frequency of the IL-6 -174 polymorphism in these three populations. A total of 348 blood samples were available for analysis. The median age for the subjects was 31 years. There were a total of 245 males and 103 females. A total of 86 Malays (25.0%), 122 Chinese (33.0%) and 140 Indians (40.0%) were genotyped. The result showed a significant difference in the G or C allele frequency of the -174 polymorphism. The total frequencies for the G and C alleles were 91.0 and 9.0%, respectively. In the Malays, the allele frequency of the C allele was 4.0% compared with 19.0% in the Indians. The C allele was not detected in the Chinese population. This finding is the first reported on the Malaysian population and may be important in determining risk of diseases associated with the IL-6 polymorphism in these three populations.
白细胞介素-6（IL-6）是一种已得到充分研究且与包括癌症在内的多种疾病相关的细胞因子。IL-6 -174（G/C）多态性的频率在不同人群中已被证实存在差异。马来西亚是一个有马来人、华人、印度人这三大主要族群的国家。在本研究中，我们旨在确定这三个族群中IL-6 -174多态性的G或C等位基因频率。共有348份血样可供分析。受试者的年龄中位数为31岁。共有245名男性和103名女性。对86名马来人（25.0%）、122名华人（33.0%）和140名印度人（40.0%）进行了基因分型。结果显示，-174多态性的G或C等位基因频率存在显著差异。G和C等位基因的总频率分别为91.0%和9.0%。在马来人中，C等位基因的频率为4.0%，而在印度人中为19.0%。在华人人群中未检测到C等位基因。这一发现是首次针对马来西亚人群的报道，可能对确定这三个族群中与IL-6多态性相关疾病的风险具有重要意义。
