Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute (INTA), University of Chile, Santiago, Chile.
Diabetes Res Clin Pract. 2009 Sep;85(3):e34-6. doi: 10.1016/j.diabres.2009.05.019. Epub 2009 Jul 9.
CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p=0.028) was observed, possibly due to an overtransmission of the G-T haplotype.
CTLA-4 在 T 细胞调节中发挥关键作用。我们分析了智利圣地亚哥 178 例 1 型糖尿病患者及其父母（534 人）的 CTLA-4+49A/G 和-318C/T 多态性。观察到与 T1D 有显著的总体关联（p=0.028），这可能是由于 G-T 单倍型的过度传递。
