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热带教学医院成人原发性颅内肿瘤就诊及诊断延迟的初步研究

Delay in presentation and diagnosis of adult primary intracranial neoplasms in a tropical teaching hospital: a pilot study.

作者信息

Idowu O E, Apemiye R A

机构信息

Division of Neurological Surgery, Department of Surgery, Lagos State University College of Medicine (LASUCOM), Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria.

出版信息

Int J Surg. 2009 Aug;7(4):396-8. doi: 10.1016/j.ijsu.2009.07.001. Epub 2009 Jul 10.

Abstract

Sixty-three adult patients with intracranial neoplasms were studied prospectively over a 2 year period. The various factors related to pre-presentation symptoms interval (PSI) and pre-diagnostic interval (PI) were noted. The mean age at presentation for all patients was 46.8 years (range 18-72 years, median 46 years). Meningiomas (30%), Pituitary tumours (18%), High-grade gliomas (14%) and craniopharyngiomas (8%) were the most common brain tumours. The median PSI of all patients was 2 year (range 2 months-5 years) with a PI of 4 weeks (range 0-8 months). The PSI and PI were longer for women with a statistical significance between the PSI and gender (p=0.016). The tumour grade was significantly correlated with PSI (p=0.000) and PI (p=0.043). Late presentation and diagnosis were due to cultural and religious beliefs compounded by self medication and financial constraint. There is the need for widespread mass enlightenment, improvement in accessibility and affordability of neuroimaging facilities coupled with subsidization of treatment.

摘要

在2年的时间里,对63例患有颅内肿瘤的成年患者进行了前瞻性研究。记录了与出现症状前间隔时间(PSI)和诊断前间隔时间(PI)相关的各种因素。所有患者的就诊平均年龄为46.8岁(范围18 - 72岁,中位数46岁)。脑膜瘤(30%)、垂体瘤(18%)、高级别胶质瘤(14%)和颅咽管瘤(8%)是最常见的脑肿瘤。所有患者的PSI中位数为2年(范围2个月 - 5年),PI为4周(范围0 - 8个月)。女性的PSI和PI更长,PSI与性别之间具有统计学意义(p = 0.016)。肿瘤分级与PSI(p = 0.000)和PI(p = 0.043)显著相关。就诊和诊断延迟是由于文化和宗教信仰,再加上自我用药和经济限制。有必要进行广泛的大众宣传,提高神经影像学检查设备的可及性和可承受性,并对治疗给予补贴。

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