Clinical and Research Center on Osteoporosis, East China Hospital, Fu Dan University, Shanghai, China.
Osteoporos Int. 2010 May;21(5):765-72. doi: 10.1007/s00198-009-1010-2. Epub 2009 Jul 14.
A recent survey of bone mineral density (BMD) in China recruited 7,042 healthy Han Chinese aged 20 years and older. The mean BMDs were different in gender, age, and region; the proportions of men and women older than 50 years with a high risk of osteoporosis were estimated as 10.4% and 31.2%, respectively
A survey of BMD was completed during 2002-2006 in China. By three-stage sampling, a total of 7,042 healthy Han Chinese aged 20 years and older were recruited in ten cities: 2,694 subjects from Beijing, Tianjin, Haerbin, Lanzhou, and Yantai of northern China and 4,348 from Shanghai, Changsha, Chengdu, Haikou, and Foshan of southern China.
Two dual X-ray absorptiometry (DXA) systems (Hologic and Lunar) were used with parallel measurements of the European spine phantoms in each center. The mean BMDs in age groups older than 50 and the peak bone mineral density (pBMD) at femoral neck and that at greater trochanter were higher for men than women, and the pBMDs for northern China were higher than those for southern China, ranging from 1% to 4%.
This work has provided two useful references for the first time: one is the estimation of the proportion and number of individuals older than 50 years with a high risk of osteoporosis, 10.4% and 12.5 million men, 31.2% and 37.2 million women, which is important for health care planning and marketing projections, and another is the conversion equations for cross-calibration among different types of DXA instruments frequently used in China.
本研究通过对中国汉族 20 岁及以上健康人群进行骨密度(BMD)调查,旨在为骨质疏松高危人群的评估和防治策略的制定提供参考依据。
采用分层整群随机抽样方法,在全国 10 个城市(北京、天津、哈尔滨、兰州、烟台和上海、长沙、成都、海口、佛山)抽取 7042 名 20 岁及以上汉族健康人群,应用双能 X 线吸收仪(Hologic 和 Lunar)对其进行骨密度检测,同时对每个检测中心的欧洲脊柱 phantom 进行双能 X 线吸收仪系统间的平行检测。
男性的 BMD 均值高于女性,50 岁及以上年龄组和股骨颈、大转子的峰值骨密度(pBMD)均高于女性;北方人群的 BMD 均值高于南方人群,范围为 1%~4%。
本研究为骨质疏松高危人群的评估和防治策略的制定提供了重要的参考依据,并为不同类型的双能 X 线吸收仪仪器间的校准提供了转换方程。