血清总胆汁酸与 20-59 岁中国成年人骨密度的相关性：一项回顾性横断面研究。
The Association of Serum Total Bile Acids With Bone Mineral Density in Chinese Adults Aged 20-59: A Retrospective Cross-Sectional Study.
机构信息
Department of Orthopedics Ward 1, Hainan Western Central Hospital, Danzhou, China.
Department of Spine Surgery, Ganzhou People's Hospital, Ganzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Apr 19;13:817437. doi: 10.3389/fendo.2022.817437. eCollection 2022.
OBJECTIVE
According to a recent study, serum total bile acids (TBA) may preserve lumbar bone mineral density (BMD) in Cushing syndrome patients, and BMD is directly linked to bone health. We were interested in examining the association between TBA and in Chinese adults aged 20-59 years.
METHODS
We retrospectively analyzed the physical examination results of 2,490 general healthy subjects in Hainan West Central Hospital. Femoral neck BMD and TBA were measured, and the relationship between TBA and femoral neck BMD was evaluated by curve fitting, a generalized additive model, and multiple linear regression analysis.
RESULTS
The fitted smooth curve and generalized additive model showed a nonlinear relationship between TBA and femoral neck BMD, and a positive correlation between TBA and femoral neck BMD was found after we made adjustments for the potential confounders.
CONCLUSION
TBA is positively associated with femoral neck BMD in Chinese adults aged 20-59 years.
目的
最近的一项研究表明，血清总胆汁酸（TBA）可能有助于库欣综合征患者保持腰椎骨密度（BMD），而 BMD 与骨骼健康直接相关。我们对中国 20-59 岁成年人中 TBA 与 BMD 之间的关系感兴趣。
方法
我们对海南西部中心医院 2490 名普通健康体检者的体检结果进行回顾性分析。测量股骨颈 BMD 和 TBA，并通过曲线拟合、广义加性模型和多元线性回归分析评估 TBA 与股骨颈 BMD 之间的关系。
结果
拟合的平滑曲线和广义加性模型显示 TBA 与股骨颈 BMD 之间呈非线性关系，且在调整潜在混杂因素后，TBA 与股骨颈 BMD 呈正相关。
结论
在中国 20-59 岁成年人中，TBA 与股骨颈 BMD 呈正相关。
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