Lal A
Department of Pharmacology, Medical College, Amritsar.
Indian J Med Res. 1991 Aug;94:316-9.
The effect of zinc sulphate on myocardial infarct size following left coronary artery branch occlusion in dogs was studied. Zinc sulphate (10 mg/kg) was administered po, 24 h and 2 h before coronary occlusion in one group of animals. The area at risk was visualised by methylene blue injected intraventricularly. The infarcted area was visualised by triphenyl tetrazolium chloride staining. The infarct size expressed as a percentage of risk zone was 76.54 +/- 3.01 per cent (mean +/- SE) in the control group and 37.96 +/- 2.20 per cent in the zinc sulphate group (P less than 0.001). Zinc sulphate appears to be a potent prophylactic agent for limiting the size of myocardial infarct in the dogs.
研究了硫酸锌对犬左冠状动脉分支闭塞后心肌梗死面积的影响。在一组动物中，于冠状动脉闭塞前24小时和2小时经口给予硫酸锌（10毫克/千克）。通过心室内注射亚甲蓝使危险区域可视化。通过氯化三苯基四氮唑染色使梗死区域可视化。梗死面积以危险区的百分比表示，对照组为76.54±3.01%（平均值±标准误），硫酸锌组为37.96±2.20%（P＜0.001）。硫酸锌似乎是一种有效的预防剂，可限制犬心肌梗死的面积。
