Sbarbati A, Morroni M, Zancanaro C, Cinti S
Istituto di Anatomia Umana ed Istologia, Università di Verona, Italy.
Int J Obes. 1991 Sep;15(9):581-7.
Interscapular brown adipose tissue (IBAT) was studied in newborn and 1, 3, 5, 7, 13, 26, 52, 78 and 104-week-old rats maintained under standard laboratory conditions in order to define its morphological modifications and assess previous statements on an involution phase of IBAT after the first weeks of extrauterine life. Serial sections were analysed morphometrically to quantify the multilocular, the monolocular and the connective-vascular components of IBAT. Morphometry shows that the IBAT weight and volume progressively increase up to the twenty-sixth week of age, these figures remaining almost constant thereafter. The volume of the unilocular and connective components increased with age. The volume of the multilocular component increases up to the sixth month of age, and slightly reduces thereafter. The number of the multilocular adipocytes is almost constant from the third week up to the second year of life. Our results suggest that, in IBAT of adult animals, despite a slight prevalence of unilocular adipocytes, the number of multilocular cells is not reduced with respect to younger animals.
为了确定肩胛间棕色脂肪组织（IBAT）的形态学变化，并评估此前关于出生后最初几周后IBAT退化期的说法，我们对在标准实验室条件下饲养的新生大鼠以及1、3、5、7、13、26、52、78和104周龄的大鼠的IBAT进行了研究。对连续切片进行形态计量分析，以量化IBAT的多泡、单泡和结缔组织-血管成分。形态计量学显示，IBAT的重量和体积在26周龄前逐渐增加，此后这些数值几乎保持不变。单泡和结缔组织成分的体积随年龄增加。多泡成分的体积在6个月龄前增加，此后略有减少。从第3周直到生命的第二年，多泡脂肪细胞的数量几乎保持不变。我们的结果表明，在成年动物的IBAT中，尽管单泡脂肪细胞略有占优，但与年轻动物相比，多泡细胞的数量并未减少。
