Cvijić G, Radojicić R, Matijasević Z, Davidović V
Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Yugoslavia.
Zoolog Sci. 1994 Oct;11(5):707-11.
The effect of dexamethasone (DEX) and corticosterone (COR) on the activity of monoamine oxidase (MAO), copper-zinc superoxide dismutase (CuZn SOD) and manganese superoxide dismutase (Mn SOD) in the rat interscapular brown adipose tissue (IBAT) were studied. DEX (1 mg/kg, i.p. for two days) significantly increased MAO activity in the IBAT as compared to the corresponding controls. On the contrary, COR, in the corresponding dose (5 mg/kg), did not affect MAO activity in the IBAT. DEX also markedly enhanced the activity of both SODs in the tissue studied, while COR was ineffective. The results suggest that there exist the differences in the effect between the synthetic glucocorticoid, such as DEX, and COR, which is a natural glucocorticoid in the rat, on the activity of IBAT enzymes studied.
研究了地塞米松（DEX）和皮质酮（COR）对大鼠肩胛间棕色脂肪组织（IBAT）中单胺氧化酶（MAO）、铜锌超氧化物歧化酶（CuZn SOD）和锰超氧化物歧化酶（Mn SOD）活性的影响。与相应对照组相比，DEX（1 mg/kg，腹腔注射，连续两天）显著增加了IBAT中的MAO活性。相反，相应剂量（5 mg/kg）的COR对IBAT中的MAO活性没有影响。DEX还显著增强了所研究组织中两种超氧化物歧化酶的活性，而COR则无效。结果表明，合成糖皮质激素如DEX与大鼠体内天然糖皮质激素COR在所研究的IBAT酶活性影响方面存在差异。
