Tervahartiala P, Kivisaari L, Kivisaari R, Virtanen I, Standertskjöld-Nordenstam C G
Department of Diagnostic Radiology, Helsinki University Central Hospital, Finland.
Invest Radiol. 1991 Oct;26(10):882-7. doi: 10.1097/00004424-199110000-00009.
The morphologic changes in healthy rat kidneys (n = 102) were studied 2 or 48 hours after intravenous injection of 1 or 3 g iodine (I)/kg of high-osmolality diatrizoate, low-osmolality iopromide and iohexol, or iso-osmolality iotrolan, as well as after 0.2 or 0.6 g/kg of the high-osmolality magnetic resonance contrast medium gadolinium DTPA. Physiologic saline was injected in controls. The kidneys were fixed by perfusion and the specimens were analyzed semiquantitatively by two independent observers blinded to the treatment. A statistically significant (P less than .01) cytoplasmic vacuolization was noticed in the proximal convoluted tubule cells 2 hours after injection of 3 g I/kg of diatrizoate or iopromide. Iohexol and iotrolan induced an even more significant (P less than .01) and longer-lasting vacuolization, but gadolinium DTPA did not produce lysosomal alterations. Although the vital cell organelles remained intact, reversible lysosomal alterations may represent the first structural signs of a threatening cellular injury.
对102只健康大鼠的肾脏进行形态学研究，在静脉注射1或3克碘（I）/千克的高渗泛影葡胺、低渗碘普罗胺和碘海醇、等渗碘曲仑后2小时或48小时，以及注射0.2或0.6克/千克的高渗磁共振造影剂钆喷酸葡胺后进行研究。对照组注射生理盐水。通过灌注固定肾脏，由两位对治疗不知情的独立观察者对标本进行半定量分析。注射3克I/千克泛影葡胺或碘普罗胺后2小时，在近端曲管细胞中观察到具有统计学意义（P小于0.01）的细胞质空泡化。碘海醇和碘曲仑引起更显著（P小于0.01）且持续时间更长的空泡化，但钆喷酸葡胺未引起溶酶体改变。尽管重要细胞器保持完整，但可逆性溶酶体改变可能是细胞损伤威胁的首个结构迹象。
