Boobis Alan, Watelet Jean-Baptiste, Whomsley Rhys, Benedetti Margherita Strolin, Demoly Pascal, Tipton Keith
Department of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, Hammersmith Campus, London.
Drug Metab Rev. 2009;41(3):486-527. doi: 10.1080/10837450902891550.
Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug-diet interactions. The potential for metabolism-based drug interactions is increasingly being taken into account during drug development, using a variety of in silico and in vitro approaches. Prediction of transporter-based interactions is not as advanced. The clinical importance of a drug interaction will depend upon a number of factors, and it is important to address concerns quantitatively, taking into account the therapeutic index of the compound.
抗过敏药物通常与其他药物联合使用，用于治疗过敏或其他病症。与许多药物一样，大多数此类药物会受到P450酶的代谢作用以及跨膜转运的影响。这就产生了相当大的药物相互作用潜力，此外还必须考虑药物与饮食的相互作用。在药物研发过程中，越来越多地使用各种计算机模拟和体外方法来考虑基于代谢的药物相互作用。基于转运体的相互作用预测则没有那么先进。药物相互作用的临床重要性取决于多种因素，重要的是要定量解决相关问题，同时考虑化合物的治疗指数。
