Nicolas Jean-Marie, Espie Pascal, Molimard Mathieu
UCB Pharma SA, Chemin du Foriest, Braine I' Alleud, B-1420 Belgium.
Drug Metab Rev. 2009;41(3):408-21. doi: 10.1080/10837450902891485.
Like any other drugs, antiallergic medications can be associated with large inter- and intraindividual variability in their disposition. The best-documented examples belong to the H1 antihistamines. Variable drugs are more likely to show unpredictable therapeutic response with both increased risks of side effects and subtherapeutic dosing in individual subjects. This article will review the main factors contributing to intervariability in pharmacokinetics with a special emphasis on gender differences, genetic polymorphism, and food habits.
与任何其他药物一样，抗过敏药物在其处置过程中可能存在较大的个体间和个体内变异性。记录最充分的例子属于H1抗组胺药。可变药物更有可能表现出不可预测的治疗反应，个体出现副作用的风险增加且剂量低于治疗量。本文将综述导致药代动力学个体间变异性的主要因素，特别强调性别差异、基因多态性和饮食习惯。
