界定整合素αvβ6在癌症中的作用。
Defining the role of integrin alphavbeta6 in cancer.
作者信息
Bandyopadhyay A, Raghavan S
机构信息
Columbia University, College of Dental Medicine and Department of Dermatology, VC12-230, 622 W 168th Street, New York, NY 10032, USA.
出版信息
Curr Drug Targets. 2009 Jul;10(7):645-52. doi: 10.2174/138945009788680374.
Abstract
Integrins are a large family of heterodimeric transmembrane receptors that mediate cell-substratum adhesion. alphavbeta6 is an epithelial-specific integrin that is a receptor for the extracellular matrix (ECM) proteins fibronectin, vitronectin, tenascin and the latency associated peptide (LAP) of TGF-beta. Integrin alphavbeta6 is not expressed in healthy adult epithelia but is upregulated during wound healing and in cancer. alphavbeta6 has been shown to modulate invasion, inhibit apoptosis, regulate the expression of matrix metalloproteases (MMPs) and activate TGF-beta1. There is increasing evidence, primarily from in vitro studies, that suggest that alphavbeta6 may actually promote carcinoma progression. In this review we summarize what has been learnt in the past few years about the role of alphavbeta6 in cancer progression.
摘要
整合素是一类大型的异二聚体跨膜受体，介导细胞与基质的黏附。αvβ6是一种上皮特异性整合素，是细胞外基质（ECM）蛋白纤连蛋白、玻连蛋白、腱生蛋白以及转化生长因子-β（TGF-β）的潜伏相关肽（LAP）的受体。整合素αvβ6在健康的成年上皮细胞中不表达，但在伤口愈合过程和癌症中会上调。αvβ6已被证明可调节侵袭、抑制细胞凋亡、调节基质金属蛋白酶（MMPs）的表达并激活TGF-β1。越来越多的证据，主要来自体外研究，表明αvβ6实际上可能促进癌进展。在这篇综述中，我们总结了过去几年中关于αvβ6在癌症进展中的作用所学到的知识。
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本文引用的文献
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Anticancer Res. 2009 Jan;29(1):125-30.
2
Endocytosis and cancer: an 'insider' network with dangerous liaisons.内吞作用与癌症：一个存在危险关联的“内部人员”网络。
Traffic. 2008 Dec;9(12):2011-21. doi: 10.1111/j.1600-0854.2008.00816.x. Epub 2008 Aug 14.
3
Overexpression of the alphavbeta6 integrin in endometrial cancer.αvβ6整合素在子宫内膜癌中的过表达。
Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):543-7. doi: 10.1097/PAI.0b013e31816bc5ee.
4
Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus.利用口蹄疫病毒的特异性决定环构建抗αvβ6整合素的单链Fv抗体。
J Mol Biol. 2008 Oct 3;382(2):385-401. doi: 10.1016/j.jmb.2008.07.013. Epub 2008 Jul 16.
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Cancer Res. 2008 May 1;68(9):3295-303. doi: 10.1158/0008-5472.CAN-08-0174.
6
Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells.整合素αvβ6对结肠癌细胞凋亡的信号传导及调控机制
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7
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