Niu Jun, Li Zequn
Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China.
Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China.
Cancer Lett. 2017 Sep 10;403:128-137. doi: 10.1016/j.canlet.2017.06.012. Epub 2017 Jun 17.
Integrins are a family of heterodimeric cell surface receptors that are expressed in most cells, where they mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrin αvβ6 is a heterodimer with αv and β6 subunits. It is epithelial-specific and strongly induced during wound healing, inflammation and carcinogenesis. Integrin αvβ6 is considered to be a prognostic indicator because it is up-regulated in various types of cancers and integrin αvβ6 expression correlates with the survival time of patients. A large body of evidence suggests that integrin αvβ6 is of great significance in tumor progression, as integrin αvβ6 has been demonstrated to modulate numerous malignant behaviors of tumor cells. A number of classic oncogenic signaling pathways are involved in integrin αvβ6-mediated tumor progression. The expression characteristics and vital effects of integrin αvβ6 in the progression of tumors has led studies to focus on integrin αvβ6-targeted tumor imaging and tumor therapy, which have subsequently made integrin αvβ6 a promising target for clinical examination and treatment. This review provides an overview of the current understanding of the roles and underlying mechanisms of integrin αvβ6 in tumors. Furthermore, the common links as well as discrepancies between independent studies are also discussed.
整合素是一类异二聚体细胞表面受体家族，在大多数细胞中表达，介导细胞间以及细胞与细胞外基质（ECM）的相互作用。整合素αvβ6是由αv和β6亚基组成的异二聚体。它具有上皮特异性，在伤口愈合、炎症和癌变过程中被强烈诱导。整合素αvβ6被认为是一种预后指标，因为它在各种类型的癌症中上调，且整合素αvβ6的表达与患者的生存时间相关。大量证据表明，整合素αvβ6在肿瘤进展中具有重要意义，因为整合素αvβ6已被证明可调节肿瘤细胞的多种恶性行为。一些经典的致癌信号通路参与整合素αvβ6介导的肿瘤进展。整合素αvβ6在肿瘤进展中的表达特征和重要作用促使研究聚焦于以整合素αvβ6为靶点的肿瘤成像和肿瘤治疗，这使得整合素αvβ6成为临床检查和治疗的一个有前景的靶点。本综述概述了目前对整合素αvβ6在肿瘤中的作用及潜在机制的理解。此外，还讨论了独立研究之间的共同联系和差异。
