Kim Chang H
Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology; School of Veterinary Medicine, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA.
Inflamm Allergy Drug Targets. 2009 Jul;8(3):221-8. doi: 10.2174/187152809788681001.
T cells play central roles in regulation of the immune system in mammals. T cell receptor alphabeta T cells that can produce the cytokine IL-17 are called Th17 cells and form a lineage of effector T cells that are distinct from Th1, Th2 and FoxP3(+) T cells. The primary function of Th17 cells is to fight infection by bacterial and fungal pathogens. Autoreactive Th17 cells are implicated in mediating inflammation in the central nerves system, joints and other tissues. Th17 cells express a number of chemokine receptors including a secondary lymphoid tissue homing receptor (CCR7), the B follicle homing receptor (CXCR5), and non-lymphoid tissue homing receptors (CCR4, CCR5, and CXCR6). While these receptors are heterogeneously expressed by Th17 cells and have the potential to guide the migration of Th17 cell subsets into various tissues, CCR6 is uniformly expressed by most Th17 cells regardless of their tissue tropism. CCR6 plays an important role in migration of Th17 cells to inflamed tissues. Another function of CCR6 is to localize Th17 cells close to CCL20 expressing cells in the intestine, which would be important for the homeostasis of Th17 cells. Thus, chemokine receptors appear to play complex roles in the biology of Th17 cells.
T细胞在哺乳动物免疫系统的调节中发挥核心作用。能够产生细胞因子IL-17的αβ型T细胞受体T细胞被称为Th17细胞，它们形成了一类不同于Th1、Th2和FoxP3(+) T细胞的效应T细胞谱系。Th17细胞的主要功能是对抗细菌和真菌病原体感染。自身反应性Th17细胞与介导中枢神经系统、关节和其他组织的炎症有关。Th17细胞表达多种趋化因子受体，包括二级淋巴组织归巢受体（CCR7）、B滤泡归巢受体（CXCR5）和非淋巴组织归巢受体（CCR4、CCR5和CXCR6）。虽然这些受体在Th17细胞中呈异质性表达，并且有可能引导Th17细胞亚群迁移到各种组织中，但无论其组织嗜性如何，大多数Th17细胞均一致表达CCR6。CCR6在Th17细胞向炎症组织的迁移中起重要作用。CCR6的另一个功能是使Th17细胞定位于肠道中表达CCL20的细胞附近，这对Th17细胞的稳态很重要。因此，趋化因子受体似乎在Th17细胞生物学中发挥着复杂的作用。
