Rathee Permender, Chaudhary Hema, Rathee Sushila, Rathee Dharmender, Kumar Vikash, Kohli Kanchan
PDM College of Pharmacy, Bahadurgarh, India.
Inflamm Allergy Drug Targets. 2009 Jul;8(3):229-35. doi: 10.2174/187152809788681029.
Flavonoids are polyphenolic compounds that occur ubiquitously in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, anti-neoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca(+2)-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed to explain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids.
黄酮类化合物是普遍存在于植物中的多酚类化合物，在体外和体内均具有多种生物学效应。已发现它们具有抗菌、抗病毒、抗溃疡、细胞毒性、抗肿瘤、致突变、抗氧化、抗肝毒性、抗高血压、降血脂、抗血小板和抗炎活性。黄酮类化合物还具有生化效应，可抑制多种酶，如醛糖还原酶、黄嘌呤氧化酶、磷酸二酯酶、Ca(+2)-ATP酶、脂氧合酶、环氧化酶等。它们对雌激素、雄激素和甲状腺激素等不同激素也具有调节作用。已发现它们在炎症的增殖期和渗出期均具有抗炎活性。已提出多种作用机制来解释黄酮类化合物的抗炎作用。本综述的目的是概述潜在抗炎黄酮类化合物的作用机制。
