Chaudhary Shikha, Sharma Shaweta, Fuloria Shivkanya, Sharma Pramod Kumar
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Uttar Pradesh, India.
Faculty of Pharmacy, AIMST University, Semeling Campus, Bedong, Kedah Aman, Malaysia.
Curr Rheumatol Rev. 2025;21(2):144-159. doi: 10.2174/0115733971280645240415101912.
This comprehensive exploration delves into the multifaceted attributes of quercetin, a flavonoid with extensive health-promoting potential. The review navigates through its fundamental properties, encompassing its chemical structure, classification as a flavonoid, and its natural prevalence in various sources. Addressing solubility, stability, and bioavailability challenges, the investigation delves into innovative isolation techniques, including solvent extraction, solid-phase extraction, natural deep eutectic solvents, supercritical fluid extraction, microwave-assisted extraction, column chromatography, and high-performance thin-layer chromatography. Transitioning into pharmacological implications, the study unveils quercetin's roles in anti-inflammatory pathways, antioxidant effects, and immune modulation, reflecting its versatile significance in health management. The review highlights its impact on wound healing processes and its potential to mitigate arthritis, elucidating its holistic contributions. Culminating in an exploration of recent studies, the analysis underscores quercetin's remarkable anti-inflammatory and anti-arthritis activities, reflecting its substantial potential across various ailments. The review concludes by projecting future trajectories, emphasizing prospects for an advanced understanding of quercetin's mechanisms, sustainable extraction techniques, clinical integration, and exploration of synergistic combinations. Collectively, this review investigation underscores quercetin's dynamic role at the intersection of natural compounds and medicinal applications, offering profound implications for well- being and health enhancement.
这项全面的探索深入研究了槲皮素的多方面特性，槲皮素是一种具有广泛健康促进潜力的类黄酮。该综述探讨了其基本性质，包括其化学结构、作为类黄酮的分类以及在各种来源中的天然存在情况。针对溶解性、稳定性和生物利用度方面的挑战，该研究深入探讨了创新的分离技术，包括溶剂萃取、固相萃取、天然低共熔溶剂、超临界流体萃取、微波辅助萃取、柱色谱法和高效薄层色谱法。在转向药理学意义方面，该研究揭示了槲皮素在抗炎途径、抗氧化作用和免疫调节中的作用，反映了其在健康管理中的多方面重要性。该综述强调了其对伤口愈合过程的影响以及减轻关节炎的潜力，阐明了其全面贡献。在对近期研究的探索中达到高潮，该分析强调了槲皮素显著的抗炎和抗关节炎活性，反映了其在各种疾病中的巨大潜力。该综述通过预测未来的发展轨迹得出结论，强调了深入了解槲皮素作用机制、可持续提取技术、临床整合以及探索协同组合的前景。总体而言，这项综述研究强调了槲皮素在天然化合物与医学应用交叉领域的动态作用，对福祉和健康提升具有深远意义。
