Keskin Göksal, Inal Ali, Ilikçi Rahşan, Baysal Ozan
DYBEA Hospital Immunology, Department, Ankara, Turkey.
Protein Pept Lett. 2009;16(7):830-3. doi: 10.2174/092986609788681689.
Familial mediterranean fever (FMF) is a familial disease characterized by recurrent episodes of febrile serositis, peritonitis, arthritis and pleuritis. Many studies have been performed is an attempt to understand the basis of the inflammatory attacts in FMF. Ghrelin, a recently described orexigene peptide is predominantly produced by stomach. Ghrelin also exerts multiple regulatory effects on immune system. It has reported that grelin has anti-inflammatory effects. There is currently no published evidence demonstrating a role for anti-inflammatory effects of ghrelin in FMF. For this reason, we investigated the role of plasma ghrelin levels in patients with FMF. Thirty seven patients with FMF and 10 healthy controls (5 female, 5 male; mean age 35.4 +/- 5.6 years) were enrolled in this study. Twenty-one patients were in active stage (10 female, 11 male, mean age; 31.0 +/- 5.4 years, mean disease duration 7.2 +/- 3.3 years) and 16 patients were in inactive stage (7 female,9 male, mean age; 33.0 +/- 6.0 years, mean disease duration; 8.7 +/- 3.2 years). Plasma ghrelin levels were determined by EIA. The mean plasma ghrelin levels were 158.4 +/- 52.9 pg/ml in patients with FMF and 56.7 +/- 7.5 pg/ml in healthy controls. The mean plasma ghrelin levels were 190.5 +/- 49.4 pg/ml in the active patients and 116.2 +/- 11.7 pg/ml in the inactive patients. Plasma ghrelin levels were significantly high in patients with FMF compared to healthy controls (p<0.001). Plasma ghrelin levels were significantly high in the active patients compared to in the inactive patients and healthy controls (p<0.001 and p<0.001 respectively). There was significantly difference between in active and inactive patients with FMF (p<0.001). As a results; Plasma ghrelin levels were high both in active and inactive patients with FMF. It is showed that ghrelin may play significant role of the pathogenesis of FMF.
家族性地中海热（FMF）是一种家族性疾病，其特征为发热性浆膜炎、腹膜炎、关节炎和胸膜炎反复发作。已经进行了许多研究，试图了解FMF中炎症发作的基础。胃泌素是一种最近描述的促食欲肽，主要由胃产生。胃泌素对免疫系统也有多种调节作用。据报道，胃泌素具有抗炎作用。目前尚无已发表的证据证明胃泌素的抗炎作用在FMF中发挥作用。因此，我们研究了FMF患者血浆胃泌素水平的作用。本研究纳入了37例FMF患者和10名健康对照者（5名女性，5名男性；平均年龄35.4±5.6岁）。21例患者处于活动期（10名女性，11名男性，平均年龄31.0±5.4岁，平均病程7.2±3.3年），16例患者处于非活动期（7名女性，9名男性，平均年龄33.0±6.0岁，平均病程8.7±3.2年）。通过酶免疫分析（EIA）测定血浆胃泌素水平。FMF患者的平均血浆胃泌素水平为158.4±52.9 pg/ml，健康对照者为56.7±7.5 pg/ml。活动期患者的平均血浆胃泌素水平为190.5±49.4 pg/ml，非活动期患者为116.2±11.7 pg/ml。与健康对照者相比，FMF患者的血浆胃泌素水平显著升高（p<0.001）。与非活动期患者和健康对照者相比，活动期患者的血浆胃泌素水平显著升高（分别为p<0.001和p<0.001）。FMF活动期和非活动期患者之间存在显著差异（p<0.001）。结果显示，FMF活动期和非活动期患者的血浆胃泌素水平均较高。表明胃泌素可能在FMF的发病机制中起重要作用。
