Mittal Ashu, Sara U V S, Ali Asgar, Aqil Mohd
ITS -Paramedical (Pharmacy) College, Ghaziabad, India.
Curr Drug Deliv. 2009 Jul;6(3):274-9. doi: 10.2174/156720109788680877.
Novel techniques for drug delivery have been investigated in human medicine in recent years. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) that can reversibly compromise the skin's barrier function and consequently allow the entry of otherwise poorly penetrating molecules into the membrane and through to the systemic circulation. A large number of fatty acids have been used as permeation enhancers. They have proven to be effective and safe sorption promoters. This present review includes the classification, feasibility and application of fatty acids as sorption promoters for improved delivery of drug through skin.
近年来，人类医学领域对新型给药技术进行了研究。药物经皮给药途径因其诸多生物医学优势而吸引了研究人员。然而，皮肤极佳的不透性是通过该途径将药物分子成功递送至体循环必须克服的最大挑战。一种长期用于改善经皮给药的方法是使用渗透促进剂（也称为吸附促进剂或加速剂），其可可逆地破坏皮肤的屏障功能，从而使原本难以穿透的分子进入膜并进入体循环。大量脂肪酸已被用作渗透促进剂。它们已被证明是有效且安全的吸附促进剂。本综述包括脂肪酸作为吸附促进剂以改善药物经皮递送的分类、可行性及应用。
