Taher Ali, Musallam Khaled M, El Rassi Fouad, Duca Lorena, Inati Adlette, Koussa Suzane, Cappellini Maria D
Department of Internal Medicine, Haematology-Oncology Division, American University of Beirut Medical Centre, Beirut, Lebanon.
Br J Haematol. 2009 Sep;146(5):569-72. doi: 10.1111/j.1365-2141.2009.07810.x. Epub 2009 Jul 13.
Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 +/- 3.43 micromol/l), serum ferritin (1023 +/- 780 ng/ml) and liver iron concentration (LIC; 9.0 +/- 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P < 0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.
在一项针对74例非输血的中间型地中海贫血（TI）患者的横断面随机研究中，非转铁蛋白结合铁（NTBI）被评估为铁过载指标。平均NTBI（2.92±3.43微摩尔/升）、血清铁蛋白（1023±780纳克/毫升）和肝脏铁浓度（LIC；9.0±7.4毫克铁/克干重）均高于参考范围水平。平均NTBI与LIC（Pearson相关性0.36；P = 0.002）和血清铁蛋白（Pearson相关性0.421；P < 0.0001）之间存在显著正相关；脾切除患者中观察到更高水平。NTBI评估有可能成为一种简单可靠的方法来确定TI患者的铁状态。
