Telles-Correia Diogo, Cortez-Pinto Helena, Barbosa António, Mega Inês, Monteiro Estela
Department of Psychiatry, Faculty of Medicine, University of Lisbon, Portugal.
BMC Gastroenterol. 2009 Jul 15;9:54. doi: 10.1186/1471-230X-9-54.
It has been demonstrated in many studies that quality of life can be improved after liver transplantation in patients with liver disease. Nevertheless, quality of life improvement in specific groups of transplanted patients such as those with Familial Amyloid Polyneuropathy has not yet been explored. The present study aimed to compare the change in quality of life following liver transplantation between patients with Familial Amyloid Polyneuropathy (FAP) and patients with liver disease.
Patient's mental quality of life showed an improvement in all liver disease patients, and a worsening in FAP patients, resulting in a significant difference between the two groups. Regarding physical quality of life, although a similar improvement was seen in both groups, FAP patients had significantly less improvement than the sub-group of decompensated liver disease (Child-Pugh B and C).
It is concluded that liver transplantation has a less beneficial impact in FAP patient's physical quality of life, probably because they are not so much disabled by their disease at the moment of liver transplantation. The lesser improvement in mental quality of life of FAP patients may be due to their particular psychological profile and greater expectations towards transplantation.
许多研究表明，肝病患者肝移植后生活质量可得到改善。然而，特定移植患者群体（如家族性淀粉样多神经病患者）的生活质量改善情况尚未得到探讨。本研究旨在比较家族性淀粉样多神经病（FAP）患者和肝病患者肝移植后生活质量的变化。
所有肝病患者的心理生活质量均有所改善，而FAP患者的心理生活质量则有所恶化，两组之间存在显著差异。关于身体生活质量，尽管两组都有类似的改善，但FAP患者的改善程度明显低于失代偿性肝病亚组（Child-Pugh B级和C级）。
得出的结论是，肝移植对FAP患者的身体生活质量的有益影响较小，可能是因为他们在肝移植时疾病导致的残疾程度没有那么严重。FAP患者心理生活质量改善较少可能是由于其特殊的心理特征以及对移植的期望较高。
