Price C E, Lowe D, Cohen A T, Reid F D, Forbes G M, McEwen J, Williams R
Department of Public Health and Epidemiology, King's College School of Medicine and Dentistry, London, UK.
J R Soc Med. 1995 Mar;88(3):130-5.
The quality of life in adult patients with chronic liver disease who were considered for transplantation was assessed prospectively over a 2 year period, for both those who did and did not subsequently receive transplants. The main outcome measures were the Nottingham Health Profile and survival. Of the 109 patients who completed an entry profile, 27 were transplanted, 71 not transplanted during the study period, and 11 rejected for transplant. Quality of life and severity of liver disease at entry was worse for the transplant group, whose survival at 15 months from entry was 81% compared with 78% for those not transplanted. Among transplant survivors there were marked improvements in quality of life, whilst amongst those not receiving transplants there was little change. In conclusion, liver transplantation was effective in improving quality of life in patients with chronic liver disease, but comparison between transplant and non-transplant patients is difficult because of differences between the groups.
在两年的时间里，对考虑进行肝移植的成年慢性肝病患者的生活质量进行了前瞻性评估，研究对象包括随后接受移植和未接受移植的患者。主要观察指标为诺丁汉健康量表和生存率。在完成初始评估的109例患者中，27例接受了移植，71例在研究期间未接受移植，11例被拒绝移植。移植组患者入组时的生活质量和肝病严重程度较差，入组15个月时移植组的生存率为81%，未移植组为78%。移植存活者的生活质量有显著改善，而未接受移植者的生活质量变化不大。总之，肝移植对改善慢性肝病患者的生活质量有效，但由于两组之间存在差异，移植患者与未移植患者之间的比较存在困难。
