Nishimura Y
Department of Orthopaedic Surgery, Nagasaki University School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1991 Sep;65(9):767-74.
Using spontaneously hypertensive rats (SHRs), attempts were made to decide whether or not mechanical stress on the femoral head plays a role in the occurrence of the femoral head lesions, namely, avascular necrosis and ossification disturbance. The following measures were taken to reduce mechanical stress: severing of the sciatic nerve, severing of both the sciatic and femoral nerves, and amputation of the hind limb on one side. The frequency of the femoral head lesions was highest in the control group (85%). It was lower in the sciatic nerve severance group, sciatic and femoral nerve severance group, and hind limb amputation group, in that order, showing a direct correlation with the level of mechanical stress. Moreover, histological abnormalities of the growth plate were observed frequently in the outer portion of the femoral head in SHRs with femoral head lesions. These findings indicate that mechanical stress causes an impairment of the femoral head cartilage, resulting in the obstruction of blood vessels leading to the epiphyseal nucleus of the femoral head.
利用自发性高血压大鼠（SHRs），试图确定股骨头的机械应力是否在股骨头病变（即缺血性坏死和骨化紊乱）的发生中起作用。采取了以下措施来减轻机械应力：切断坐骨神经、切断坐骨神经和股神经、一侧后肢截肢。对照组中股骨头病变的发生率最高（85%）。在坐骨神经切断组、坐骨神经和股神经切断组以及后肢截肢组中，该发生率依次降低，与机械应力水平呈直接相关。此外，在患有股骨头病变的SHRs的股骨头外侧部分，生长板的组织学异常经常被观察到。这些发现表明，机械应力会导致股骨头软骨受损，从而导致通向股骨头骨骺核的血管阻塞。
