Silberfarb P M, Anderson K M, Rundle A C, Holland J C, Cooper M R, McIntyre O R
Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
J Clin Oncol. 1991 Dec;9(12):2219-24. doi: 10.1200/JCO.1991.9.12.2219.
Two hundred ninety patients with a recent diagnosis of multiple myeloma were studied psychologically at the time of initial treatment. Physician- and patient-completed psychosocial scales were correlated with physical variables used to measure tumor load and physical status. A logistic regression model was used to analyze objective response to treatment. Indirect measures of response to treatment were obtained, and factors influencing survival duration were studied using a Cox regression model. If physical variables were controlled, there were no significant correlations between psychologic scores on entry and response to treatment or survival duration. Thus, the notion that mood influences disease outcome once the disease process has begun in patients with multiple myeloma is not supported by this data set.
对290名近期诊断为多发性骨髓瘤的患者在初始治疗时进行了心理研究。医生和患者完成的社会心理量表与用于测量肿瘤负荷和身体状况的生理变量相关。使用逻辑回归模型分析对治疗的客观反应。获得了治疗反应的间接测量值，并使用Cox回归模型研究了影响生存时间的因素。如果控制生理变量，入院时的心理评分与治疗反应或生存时间之间没有显著相关性。因此，该数据集不支持多发性骨髓瘤患者疾病进程开始后情绪会影响疾病结局这一观点。
