Frick E, Motzke C, Fischer N, Busch R, Bumeder I
Department of Psychotherapy and Psychosomatics, Psychiatric Clinic, Ludwig-Maximilians University of Munich, Germany.
Psychooncology. 2005 Sep;14(9):759-70. doi: 10.1002/pon.908.
Previous research discussed the predictive value of psychosocial variables along with biomedical predictors for survival; such as affective functioning and quality of life. The present study addresses the following research question: does perceived social support prior to PSBCT have an impact on post-transplant survival?
Ninety-nine patients suffering from Multiple Myeloma (n=55), Non-Hodgkin Lymphoma (n=33), and other malignancies (n=11) completed the Illness Specific Scales of Social Support (ISSS) before undergoing PBSCT. ISSS is comprised of the subscales 'positive social support' and 'problematic social support', e.g. criticising, victimising, or avoiding interactions.
The mean score in the subscale 'positive social support' was 3.2 (S.D. 0.54; range 0 until 4), in the subscale 'negative social support' 0.94 (S.D. 0.53). There was no association between positive interactions and survival following PBSCT. Conversely, those patients perceiving problematic social support, showed a correspondence with poor survival following PBSCT (RR=3.649; p=0.015; Cox-regression analysis). The following variables were controlled: Karnofsky Performance Status, interferon treatment, depression and participation in psychotherapy.
Differentiating between positive and problematic interactions prior to PBSCT helps to recognise detrimental forms of social support. Future research should investigate the clinical implications and help tailor psychotherapeutic intervention.
先前的研究探讨了社会心理变量与生物医学预测指标对生存的预测价值，如情感功能和生活质量。本研究提出以下研究问题：在进行自体外周血干细胞移植（PBSCT）之前感知到的社会支持是否会对移植后的生存产生影响？
99例患有多发性骨髓瘤（n = 55）、非霍奇金淋巴瘤（n = 33）和其他恶性肿瘤（n = 11）的患者在接受PBSCT之前完成了疾病特异性社会支持量表（ISSS）。ISSS由“积极社会支持”和“问题性社会支持”两个分量表组成，例如批评、伤害或避免互动。
“积极社会支持”分量表的平均得分为3.2（标准差0.54；范围0至4），“消极社会支持”分量表的平均得分为0.94（标准差0.53）。PBSCT后积极互动与生存之间没有关联。相反，那些感知到问题性社会支持的患者，在PBSCT后生存情况较差（相对风险=3.649；p = 0.015；Cox回归分析）。对以下变量进行了控制：卡氏功能状态、干扰素治疗、抑郁和参与心理治疗。
区分PBSCT之前的积极和问题性互动有助于识别有害的社会支持形式。未来的研究应调查其临床意义，并有助于定制心理治疗干预措施。
