高安动脉炎中缺乏抗脂蛋白脂肪酶抗体。

Lack of antilipoprotein lipase antibodies in Takayasu's arteritis.

作者信息

de Carvalho Jozélio Freire, Pereira Rosa Maria Rodrigues, Viana Vilma Santos Trindade, Bonfá Eloísa, Shoenfeld Yehuda

机构信息

Disciplina de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, 0124-6903 São Paulo, Brazil.

出版信息

Clin Dev Immunol. 2009;2009:803409. doi: 10.1155/2009/803409. Epub 2009 Jul 12.

DOI:10.1155/2009/803409

PMID:19606253

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2709718/

Abstract

BACKGROUND

Antilipoprotein lipase (anti-LPL) antibodies were described in rheumatic diseases. In systemic lupus erythematosus they were highly associated with inflammatory markers and dyslipidemia, and may ultimately contribute to vascular damage. The relevance of this association in Takayasu's arteritis, which is characterized by major inflammatory process affecting vessels, has not been determined.

OBJECTIVES

To analyze the presence of anti-LPL antibodies in patients with Takayasu's arteritis and its association with inflammatory markers and lipoprotein risk levels. Methods. Thirty sera from patients with Takayasu's arteritis, according to ACR criteria, were consecutively included. IgG anti-LPL was detected by a standard ELISA. Lipoprotein risk levels were evaluated according to NCEP/ATPIII. Inflammatory markers included ESR and CRP values.

RESULTS

Takayasu's arteritis patients had a mean age of 34 years old and all were females. Half of the patients presented high ESR and 60% elevated CRP. Lipoprotein NCEP risk levels were observed in approximately half of the patients: 53% for total cholesterol, 43% for triglycerides, 16% for HDL-c and 47% for LDL-c. In spite of the high frequency of dyslipidemia and inflammatory markers in these patients no anti-LPL were detected.

CONCLUSIONS

The lack of anti-LPL antibodies in Takayasu's disease implies distinct mechanisms underlying dyslipidemia compared to systemic lupus erythematosus.

摘要

背景

抗脂蛋白脂肪酶（anti-LPL）抗体在风湿性疾病中有所描述。在系统性红斑狼疮中，它们与炎症标志物和血脂异常高度相关，最终可能导致血管损伤。这种关联在以影响血管的主要炎症过程为特征的大动脉炎中的相关性尚未确定。

目的

分析大动脉炎患者中抗LPL抗体的存在情况及其与炎症标志物和脂蛋白风险水平的关联。方法：根据美国风湿病学会（ACR）标准，连续纳入30例大动脉炎患者的血清。通过标准酶联免疫吸附测定（ELISA）检测IgG抗LPL。根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP/ATPIII）评估脂蛋白风险水平。炎症标志物包括血沉（ESR）和C反应蛋白（CRP）值。

结果

大动脉炎患者的平均年龄为34岁，均为女性。一半患者血沉升高，60%患者CRP升高。约一半患者观察到脂蛋白NCEP风险水平：总胆固醇为53%，甘油三酯为43%，高密度脂蛋白胆固醇（HDL-c）为16%，低密度脂蛋白胆固醇（LDL-c）为47%。尽管这些患者血脂异常和炎症标志物的发生率很高，但未检测到抗LPL抗体。