Pellat B, Arreto C D, Vandermander J
U.F.R. d'Odontologie Paris V.
J Parodontol. 1991 Sep;10(3):317-26.
Destructive periodontal diseases are characterized by tissue breakdown partly mediated by various enzymes originating from bacteria and/or tissue. Collagen and fibronectin are two of the main substrates available for enzyme activity. Since chlorhexidine is largely used during and after periodontal therapy, we have investigated the effects of chlorhexidine upon some bacterial proteases. Our data indicate that chlorhexidine inhibits, on a dose-dependent manner, both fibronectin and collagen hydrolysis mediated by either bacteroides (porphyromonas) gingivalis or bacteroides intermedius. Thus, it might be hypothesized that a side from its bactericidal activity, chlorhexidine helps to prevent periodontal tissue destruction directly by enzyme inhibition.
破坏性牙周疾病的特征是组织破坏，部分是由源自细菌和/或组织的各种酶介导的。胶原蛋白和纤连蛋白是酶活性的两种主要作用底物。由于洗必泰在牙周治疗期间及之后大量使用，我们研究了洗必泰对某些细菌蛋白酶的影响。我们的数据表明，洗必泰以剂量依赖性方式抑制牙龈卟啉单胞菌或中间普氏菌介导的纤连蛋白和胶原蛋白水解。因此，可以推测，除了其杀菌活性外，洗必泰通过抑制酶直接有助于防止牙周组织破坏。
